沈祥春
发布时间: 2022-04-26 浏览次数: 20

沈祥春简介


沈祥春,男,19731月,中国药科大学博士学位,南京中医药大学中药学博士后,Texas A&M HSC访问学者,二级教授,现任贵州医科大学副校长、药学院院长,博士、硕士研究生导师,博士后合作导师,贵州省核心专家、国务院政府特殊津贴、教育部新世纪人才、贵州省优秀科技工作者、贵州省优秀博士研究生导师,主持国家自然科学基金8项,省部级科研项目10余项,获得省部级科技进步奖3项,主要从事心脑血管药物药理、天然功能物质化学生物学领域的研究。

邮箱:shenxiangchun@126.comsxc@gmc.edu.cn

  

19929-19977月,成都中医药大学,药学院,学士;

19989-20016月,南京中医药大学,药学院,硕士;

20019-20046月,中国药科大学,药学院,博士;

20049-200712月,贵州医科大学,基础医学院,副教授

20122-20132月,Texas A&M HSC,访问学者

200712月至今,贵州医科大学,基础医学院、药学院、教授

 

【主持项目】

1.     基于Nrf2-mTORC1 信号的环维黄杨星D 调控心肌细胞线粒体自噬改善糖尿病心肌病的实验研究,国家自然科学基金,主持,2021.1-2024.12

2.     喀斯特地区民族药物中有效成分心肌保护作用及机制研究,国家自然科学基金喀斯特中心项目,主持,2019.01-2022.12

3.     糖尿病血管内皮损伤PPAR-γ/NF-κB 调控机制及艳山姜挥发油干预作用的实验研究,国家自然科学基金,2018.01-2021.12

4.     艳山姜挥发油调控müller 细胞PPARγ-Nrf2 信号改善糖尿病视网膜病变的机制研究,贵州省科技厅,主持,2020.02-2024.03

【近期发表论文】

1. Chen TT, Zhou X, Xu YN, Li Y, Wu XY, Xiang Q, Fu LY, Hu XX, Tao L*, Shen XC*.Gastrodin ameliorates learning and memory impairment in rats with vascular dementia by promoting autophagy flux via inhibition of the Ca2+/CaMKII signal pathway. Aging (Albany NY), 2021 Mar 10;13(7):9542-9565. doi: 10.18632/aging.202667.

2. Zhang YY, He L,Tu MX, Huang M, Chen Y, Pan D, Peng JQ, Shen XC*.The ameliorative effect of terpinene-4-ol on ER stress-induced vascular calcification depends on Sirt1-mediated regulation of perk acetylation. Pharmacological Research, 2021,170:105629(1-15).

3. Zhang GQ, Wang SQ, Chen Y, Fu LY, Xu YN, Li L, Tao L*, ShenXC*.MicroRNAs regulating mitochondrial function in cardiac diseases. Frontiers in Pharmacology, 2021,12:663322. doi:10.3389/fphar.2021.663322

4. Varier KM, Dhandapani H, Liu WL, Song JL, Wang CL, Hu AL, Ben-David Y*, Shen XC*, Li YM*, Gajendran B*. An immunotherapeutic approach to decipher the role of long non-coding RNAs in cancer progression, resistance and epigenetic regulation of immune cells. Journal of Experimental & Clinical Cancer Research, 2021,40: 242. Https://doi.org/10.1186/s13046-021-01997-5.

5. Pan D, Zhang W,Zhang NL, Xu YN, Peng JQ, Chen Y, Zhang YY, Shen XC*. Oxymatrine synergistically enhances doxorubicin anticancer effects in colorectal cancer. Front Pharmacol, 12: 673432. Doi: 10.3389/fphar.2021.673432.

6. Wu XJ, Yang H, Li W, Tao L, Wang QT, Jin YZ, Sun XC, Shen XC*. Multiparametric miRNAs profiling by polymerization induced fluorescence-off amplification for acute myocardial infarction diagnosis. Sensors and Actuators B: Chemical, 2021, doi.org/10.1016/j.snb.2021. 130315

7. Guo QQ, Guo HL, Lan TY, Chen Y, Chen XY, Feng Y, Luo YJ, Yao YF, Li YF, Pan XH, Xu YN, Tao L, Liu YJ, Shen XC*. Co-delivery of antibiotic and baicalein by using different polymeric nanoparticle cargos with enhanced synergistic antibacterial activity. International Journal of Pharmaceutics, 2021,599: 120419.

8. Xiao T, Luo ZH, Guo ZH, Wang XD, Ding M, Wang W, Shen XC*, Zhao YQ*. Multiple roles of black raspberry anthocyanins protecting against alcoholic liver disease. Molecules,2021,26:2313.

9. Peng JQ, Jiang ZH, Wu GP, Cai ZM, Du QM, Tao L, Zhang YY, Chen Y, Shen XC*. Improving protection effects of eucalyptol via carboxymethyl chitosan-coated lipid nanoparticles on hyperglycaemia-induced vascular endothelial injury in rats. Journal of Drug Targeting, 2021, 29:5(520-530), DOI: 10.1080/1061186X.2020.1859514

【发明专利】

1.   艳山姜挥发油滴丸及其制备方法,发明专利,专利号:ZL 2014 1 0341087.9

2.    一种阿司匹林磷脂复合物及其制备方法,发明专利,专利号:ZL 2016 1 0539582.X

3.   阿司匹林脂微球制剂及其制备方法,发明专利,专利号:ZL 201410116135.4

4.   一种阿司匹林PEG-PLGA 微球及其制备方法,发明专利,专利号:ZL 201410298255.0

5.   一种丹参酮ⅡA 微球制剂的制备方法,发明专利,专利号:ZL201410795674.5

 

 


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