常用句型：
1. In our recent works, we performed a series of studies on the biological role of miR-7 in inflammation-related diseases. Most importantly, we revealed that C/EBPα/miR-7 axis controls CD4+ T cell activation and function and orchestrates the pathology of experimental autoimmune hepatitis (EAH).
在我们最近的工作中，我们对miR-7在炎症相关疾病中的生物学作用进行了一系列的研究。其中最重要的是：我们发现C/EBPα/miR-7轴控制CD4+T细胞的激活和功能，并调控实验性自身免疫性肝炎（EAH）的病理进程。
2. Meanwhile, we also found that miR-7 could regulate the function of other immune-related cells, such as macrophages and neurons and contribute to the development of these related diseases.
同时，我们还发现：miR-7可以调节其他免疫相关细胞的功能，如巨噬细胞和神经元，并促成相关疾病的发展。
3. Briefly speaking, in our series works, we reveal that miR-7 might be a novel promising regulator in immune reaction-related diseases.
简而言之，在我们的系列工作中，我们揭示了miR-7可能是免疫反应相关疾病中一个新的且有前途的调节分子。
4. Lipid metabolism was defective in the chronic phase but was transiently activated in the very early stages of ischemia-induced injury, where we discovered increased lipid deposition and increased fatty acid β-oxidation.
脂质代谢在慢性阶段是有缺陷的，但在缺血诱导损伤的早期阶段被短暂激活，在激活的同时我们发现脂质沉积增加，脂肪酸β氧化增加。
5. Perilipin 2 was identified as a surface marker of intracellular lipid droplets, and its knockdown in vitro disrupted cell energy state maintenance during lipid accumulation. Surveying epithelial cells across nephron segments identified shared and unique injury responses.
Perilipin 2被鉴定为细胞内脂滴的表面标记物，其体外敲除会破坏脂质积累过程中细胞能量状态的维持。通过对肾单位节段上皮细胞的调查，发现了共有的和独特的损伤反应。
6. Stromal cells exhibited high heterogeneity and contributed to fibrogenesis by epithelial-stromal crosstalk.
间质细胞表现出高度的异质性，并通过上皮-间质串扰促进纤维形成。
7. This paper summarizes the new WHO classification scheme for myeloid neoplasms and provides an overview of the principles and rationale underpinning changes from the prior edition.
本文总结了世界卫生组织对髓系肿瘤的新分类方案，并概述了与之前版本之间变化的原则和理论基础。
8. The aim of this paper is to provide an overview of the new edition of the WHO classification for myeloid tumors.
这篇论文的目的是提供一个针对新版世界卫生组织对髓系肿瘤分类的概述。
9. This is in line with previous editions, with expanded numbers of disease types and subtypes that are molecularly defined.
这与以前的版本是一致的，增加了分子层面定义的疾病类型和亚型的数量。
10. The classification recognizes well-differentiated systemic mastocytosis (WDSM) as morphologic pattern that can occur in any SM subtype, characterized by round and well-granulated mast cells usually heavily infiltrating the bone marrow.
该分类办法认为高分化的系统性肥大细胞增多症(WDSM)是一种形态学模式，可发生在任何SM亚型，其特征是圆形、颗粒良好的肥大细胞常严重浸润骨髓。
11. In addition, there are significant genetic differences among EMZLs arising in different anatomic sites.
此外，EMZLs在不同解剖部位间存在显著的遗传学差异。
12. Considerable evidence suggests that adrenergic signaling played an essential role in tumor progression. However, its role in hepatocellular carcinoma (HCC) and the underlying mechanisms remain unknown.
大量证据表明，肾上腺素能信号在肿瘤进展中起着重要作用。然而，其在肝细胞癌(HCC)中的作用及其机制尚不清楚。
13. Autophagy regulation by ADRB2 was assessed in immunoblotting, immunofluorescence and immunoprecipitation assays.
通过免疫印迹法、免疫荧光法和免疫沉淀法评估ADRB2对自噬的调节作用。
14. Recently, it has been reported that sympathetic and parasympathetic nervous systems in prostate tumors contribute to prostate cancer development and progression in animal model.
近年来，有研究报道在动物模型中，前列腺肿瘤的交感神经和副交感神经系统参与了前列腺癌的发生发展。
15. The liver, too, is innervated by the autonomic nervous system, which has been shown to regulate numerous physiological and pathological events.
肝脏也受自主神经系统支配，该系统已被证明可调节多种生理和病理事件。
16. Despite rapid advances in genome editing technologies, the majority of the>75,000 known human genetic variants associated with diseases remain difficult to correct or install in most therapeutically relevant cell types.
尽管基因组编辑技术发展迅速，在已知的与人类疾病相关的>75000个基因突变中，大多数突变位点仍难以被矫正或在大多数类型的治疗相关细胞系中启动表达。
17. In this study, through rational design we determined a key mutation in eTadA, D108Q, that is responsible for decreasing cytosine catalysis activity.
在本研究中，通过合理的设计，我们确定了eTadA中的一个关键突变D108Q，该突变是导致胞嘧啶催化活性降低的原因。
18. Given that other mutations that affected P48 also similarly decreased the ratio of adenine editing to cytosine editing, the cytosine specificity can probably be attributed to a change in the conformation of the main chain that consequently affects the orientations of neighboring residues.
考虑到其他影响P48的突变也同样降低了腺嘌呤至胞嘧啶编辑的比例，胞嘧啶的特异性可能归因于主链构象的变化，从而影响了邻近残基的取向。
19. Since the early nineties, many studies have been performed to examine the incidence of adverse events, with reported incidence rates ranging from 3 to 17% of all hospital admissions.
自20世纪90年代初以来，开展了许多研究来评估不良事件的发生率，据报告，发生率占所有住院患者中的3% ~ 17%。
20. Improvements can only be achieved if the interventions tackle the dominant underlying causes.
要想有所改善，就必须采取措施解决根本问题。
21. Based on the previous histological classification of gliomas from grade I to IV in WHO classification in 2016, molecular biomarkers of different tumor types were updated in WHO CNS5 in 2021, bringing more benefits and meaningful instructions to clinic.
在2016年WHO分类中胶质瘤的组织学分级从I级到IV级的基础上，2021年WHO CNS5增加了不同肿瘤类型的分子生物标志物，为临床带来了更多的益处和有意义的指导。
22. Currently, standard magnetic resonance imaging could provide the most initial and sensitive diagnosis to GBM, while GBM diagnosed with such method have usually developed into advanced stage.
目前，标准磁共振成像是GBM最早、最敏感的诊断方法，但这种方法诊断的GBM通常已经是晚期。
23. Generally, most of the median overall survival of LGG patients are more than 10 years, only those with diffuse astrocytoma with IDH-WT are around 5 years.
一般来说，大部分LGG患者的中位总生存期在10年以上，但弥漫性星形细胞瘤合并IDH-WT患者的中位总生存期在5年左右。
24. WHO grade I glioma, most of which is pilocytic astrocytoma, presents excellent prognosis, with reported 10 years overall survival as high as 100% after standard gross total resection. To WHO grade II glioma, 5 years survival rate of oligodendroglioma reaches 81%, while diffuse astrocytoma only reaches 50%.
WHO I级胶质瘤大多为毛细胞星形细胞瘤，预后良好，据报道，标准病灶全切术后10年总生存率高达100%。对于WHO二级胶质瘤，少突胶质瘤5年生存率达81%，而弥漫性星形细胞瘤5年生存率仅为50%。
25. Retrospective RNA-seq data analysis was conducted in a cohort of 313 patients with glioma in the Chinese Glioma Genome Atlas (CGGA) database and 603 patients in The Cancer Genome Atlas (TCGA) database.
对中国胶质瘤基因组图谱(CGGA)数据库中的313例胶质瘤患者和肿瘤基因组图谱(TCGA)数据库中的603例胶质瘤患者进行回顾性RNA-seq数据分析。
26. Traditionally, glioblastoma was identified with a highly immunosuppressive tumor microenvironment. However, immune checkpoint inhibitors targeting PD-1 and CTLA 4 did not show perspective potentials in clinical trials.
传统观念上，胶质母细胞瘤具有高度免疫抑制的肿瘤微环境。然而，靶向PD-1和CTLA 4的免疫检查点抑制剂在临床试验中没有显示出临床潜力。
27. Many different actors such as microglial cells, macrophages, neuronal precursor cells, vascular cells, fibroblasts, and immune cells such as dendritic cells, leukocytes, or natural killer cells take part in the TME, inter alia for steering of tumor characteristics like growth and diffusion but also therapy resistance.
许多不同的细胞，如小胶质细胞、巨噬细胞、神经前体细胞、血管细胞、成纤维细胞和免疫细胞，如树突状细胞、白细胞或自然杀伤细胞，都参与TME，调控肿瘤的生物学功能，如生长和扩散，以及治疗耐药。
28. The interactions between intrinsic properties of glioma cells and their microenvironment strongly influence the treatment responses.
胶质瘤细胞的内在特性及其微环境之间的相互作用显著影响治疗效果。
29. To establish new, effective therapeutic approaches, it is even more important to understand the interplay of intrinsic (molecular) properties and the associated immune profiles of TME.
为了开发新的、有效的治疗方法，了解TME的内在(分子)特性和相关免疫谱的相互作用是必要的。
30. Understanding communication processes between TME, GCSs, and developed glioma cells is indispensable to identify new therapeutic targets and treatment regimens against glioma and rethink old therapy strategies.
了解TME、GCSs和发育的胶质瘤细胞之间的通讯过程，对于确定新的胶质瘤治疗靶点和治疗方案以及重新利用旧的治疗策略是必不可少的。
31. Gliomas within the insular region represent one of the most challenging problems in neurosurgical oncology.
脑岛区胶质瘤是神经外科肿瘤学中最具挑战性的疾病之一。
32. Traditionally, the choice of transsylvian versus transcortical corridors has been based on historical practice at individual institutions or anecdotal experiences of individual surgeons.
传统上，选择经椎体和经皮质路径是基于个别临床机构的既往实践或个别外科医生的临床经验。
33. A recent retrospective study comparing both approaches in 100 consecutive patients reported that surgeons were more likely to choose the transcortical approach over the transsylvian approach for larger gliomas (p = 0.02) and for gliomas located in Zone III (p < 0.01).
最近的一项回顾性研究在100例患者中比较了两种手术入路，报告称，对于较大的胶质瘤和位于III区胶质瘤，外科医生更可能选择经皮质入路而不是经侧裂入路。
34. A combined approach utilizing the benefits of both the transsylvian and transcortical corridors has been advocated to yield optimal results for giant tumors.
一种综合利用经侧裂入路和经皮质的入路的优点的方法被提倡为巨大肿瘤产生最佳的结果。
35. Functional MRI (fMRI) and diffusion tensor imaging (DTI) tractography are often employed to aid in safe insular glioma resection.
功能磁共振成像(fMRI)和弥散张量成像(DTI)常用于协助脑岛神经胶质瘤安全切除。
36. Intraoperative MRI can help assess the degree of residual tumor at the medial border and allow for re-registering of the navigation software during late stages of the resection.
术中MRI可以帮助评估内侧边缘残留肿瘤的程度，并允许在切除后期再定位。
37. Developing successful treatments for glioma requires faithful in vivo disease modeling and rigorous preclinical testing.
研制成功的胶质瘤治疗方法需要可靠的体内疾病模型和严格的临床前试验。
38. We anticipate the first international PRISMA symposium to be filled with fervent enthusiasm and active academic interaction.
我们期待着首届PRISMA国际研讨会上充满热烈积极的学术互动。
39. The cells were washed three times with 1 mL of cold PBS (pH 7.4,0.01 M) before experiments.
细胞在实验前用冷PBS清洗三次。
40. The pharmacokinetics experiment was carried out with normal male KM mice.
对正常小鼠进行药代动力学实验。
41. All the data were analyzed by Graph Pad Prism 5.0 and Origin8 software.
所有数据实验软件Graph Pad Prism 5.0 and Origin8 进行分析。
42. However, there have been few studies on the association between A and B.
然而，只有很少的研究探讨A 和B 的关系。
43. Understanding the role of A could lead to novel therapeutic strategies for glomerular disease.
了解A在疾病中扮演的角色，可能有助于寻找治疗肾小球疾病的新方法。
44. The loss of kidney function in CKD is progressive and irreversible.
慢性肾脏病患者的肾功能丢失及肾功能不全进展不可逆。
45. New biomarkers enabling diagnosis of renal dysfunction at an early stage need to be developed.
需挖掘在早期能诊断肾功能异常的新指标。
常用词汇或短语：
The aim of; in line with; In addition; recent studies have suggested that; it has been reported that; be characterized by; we demonstrate that; we confirmed that; To address the role of; it is notable that; By contrast; in contrast; Consistently; evaluate the effect of; we hypothesized that; dramatically; as well as; comprise; studies have shown that; Although various approaches have been shown; it is possible to; a promising new member in; To show the potential of; establish a cell line; Analysis of; implying that; We demonstrate that; Conventional wisdom held that; These studies identified; This is an important finding in the understanding of the；Our results demonstrated that；From the result， it is clear that；The aim of this article is to provide a comprehensive review of the; by summarizing；This review gives new insights into.
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